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KMID : 0900220080150020108
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대한비과학회지
2008 Volume.15 No. 2 p.108 ~ p.114
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Expression of p53, p21, Cycin D1, and Ki-67 in Sinonasal Tumors
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Jeong Ha-Min
Yun Ki-Jung
Lee Jae-Hoon
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Abstract
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Background and Objectives: The goal of this study is to investigate alterations of cell-cycle-related molecules, including p53, p21, cyclin D1 and Ki-67, in tumors arising in the sinonasal region.
Materials and Methods : The study materials were 16 specimens of normal nasal mucosa, 16 inverted papillomas (IPs) and 12 sinonasal squamous cell carcinomas. The p53, p21, cyclin D1 and Ki-67 expression was assessed by immunohistochemical staining.
Result: IP and squamous cell carcinoma showed significant increase in the expression of p53, cyclin D1 and Ki-67 than normal mucosa. The expression of p53, cyclin D1 and Ki-67 of the carcinoma was stronger than the IP. But, the p21 expression was not associated with the IP and carcinoma.
Conclusion: Increased levels of p53, cyclin D1 and Ki-67 expression correlate with increased cell proliferation in the tumors of sinonasal regions. These findings indicate that p53, cyclin D1 and Ki-67 expression may be useful markers for the dysregulations of cell kinetics in the tumors of sinonasal region.
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KEYWORD
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Inverted papilloma, Sinonasal squamous cell carcinoma, p53, Cyclin D1, Ki-67
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